Remote processing of firm microdata at the Bank of Italy

Providing the possibility to run personalised econometric/statistical analyses on the appropriate data sets by remote processing allows greater flexibility in the production of economic information. Binding confidentiality requirements are required with business survey data. The Bank of Italy's infrastructure allows its business survey data to be exploited, while preserving anonymity of individual data. The system is based on the LISSY platform and has been already adopted by the Luxembourg Income Study (LIS) and other research centres. Firms' privacy is safeguarded by forbidding potentially confidentiality-breaking programme statements and by denying the visualisation of individual data. Data confidentiality is protected by removing key identifiers from the database and by trimming data in the right tail of the distribution. The platform provides its services through plain-text e-mails. The authorised user sends an e-mail containing an identifying header followed by a statistical programme to a predetermined address. The system checks the validity of the header, strips out the code and submits it in a batch to one of the econometric/statistical packages available (SAS and Stata). The outputs are mailed back to the user after passing an array of automatic and manual checks.microdata, confidentiality, remote access

Microbiota and chronic inflammatory arthritis. an interwoven link

Background: Only recently, the scientific community gained insights on the importance of the intestinal resident flora for the host's health and disease. Gut microbiota in fact plays a crucial role in modulating innate and acquired immune responses and thus interferes with the fragile balance inflammation versus tolerance. Main body: Correlations between gut bacteria composition and the severity of inflammation have been studied in inflammatory bowel diseases. More recently similar alterations in the gut microbiota have been reported in patients with spondyloarthritis, whereas in rheumatoid arthritis an accumulating body of evidence evokes a pathogenic role for the altered oral microbiota in disease development and course. In the context of dysbiosis it is also important to remember that different environmental factors like stress, smoke and dietary components can induce strong bacterial changes and consequent exposure of the intestinal epithelium to a variety of different metabolites, many of which have an unknown function. In this perspective, and in complex disorders like autoimmune diseases, not only the genetic makeup, sex and immunologic context of the individual but also the structure of his microbial community should be taken into account. Conclusions: Here we provide a review of the role of the microbiota in the onset, severity and progression of chronic inflammatory arthritis as well as its impact on the therapeutic management of these patients. Furthermore we point-out the complex interwoven link between gut-joint-brain and immune system by reviewing the most recent data on the literature on the importance of environmental factors such as diet, smoke and stress